GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs7116495 | 1 | rs482013 | chr11:71803962 | FAM86C | chr11:71498557-71512276:+ | 0.32 | 3.91 | 0.000107 | Severe influenza A (H1N1) infection |
| THCA | cis | rs4820294 | 1 | rs4820294 | chr22:38071043 | LGALS2 | chr22:37966254-37976024:- | 0.14 | 3.78 | 0.000174 | Fat distribution (HIV) |
| THCA | cis | rs4820294 | 1 | rs4820294 | chr22:38071043 | PDXP | chr22:38054737-38062939:+ | -0.18 | -3.35 | 0.00086 | Fat distribution (HIV) |
| THCA | cis | rs4820294 | 1 | rs4820294 | chr22:38071043 | SH3BP1 | chr22:38030661-38062939:+ | 0.12 | 3.79 | 0.000168 | Fat distribution (HIV) |
| THCA | cis | rs2076028 | 1 | rs4820345 | chr22:39091151 | JOSD1 | chr22:39081549-39096459:- | -0.14 | -3.72 | 0.000225 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs4820345 | chr22:39091151 | LOC646851 | chr22:38974125-39052634:- | 0.13 | 3.47 | 0.000558 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs4820345 | chr22:39091151 | TOMM22 | chr22:39077954-39080763:+ | -0.17 | -3.52 | 0.000464 | Resting heart rate |
| THCA | cis | rs4820539 | 1 | rs4820539 | chr22:23477970 | GNAZ | chr22:23412669-23467221:+ | 0.27 | 5.91 | 6.66E-9 | Bone mineral density |
| THCA | cis | rs4820539 | 1 | rs4820539 | chr22:23477970 | RAB36 | chr22:23487513-23506531:+ | -0.17 | -3.38 | 0.000786 | Bone mineral density |
| THCA | cis | rs4820834 | 1 | rs4820834 | chr22:30751627 | MTP18 | chr22:30805176-30825041:+ | 0.23 | 3.36 | 0.00083 | Coronary artery calcification |
| THCA | cis | rs4141404 | 1 | rs4820963 | chr22:31698166 | RNF185 | chr22:31556138-31603004:+ | -0.29 | -5.39 | 1.13E-7 | Paclitaxel-induced neuropathy |
| THCA | cis | rs2076028 | 1 | rs4821798 | chr22:39021165 | JOSD1 | chr22:39081549-39096459:- | -0.13 | -3.47 | 0.000561 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs4821798 | chr22:39021165 | LOC646851 | chr22:38974125-39052634:- | 0.13 | 3.67 | 0.000272 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs4821798 | chr22:39021165 | TOMM22 | chr22:39077954-39080763:+ | -0.17 | -3.91 | 0.000106 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs4821808 | chr22:39065739 | JOSD1 | chr22:39081549-39096459:- | -0.15 | -4.03 | 6.54E-5 | Resting heart rate |